If you have sleep problems and take prescription medications, ask your doctor if one of the drugs could be the cause. In a study in Mayo Clinic Proceedings, investigators assessed 74 research reviews involving 88 drugs and found that 19 of them increased sleep problems.
Classes of drugs most likely to cause insomnia include certain antidepressants (notablyselective serotonin reuptake inhibitors, or SSRIs, and tricyclics), systemic corticosteroids, acetylcholinesterase inhibitors (used to treat Alzheimer's disease and glaucoma), and COMT inhibitors (for Parkinson's disease).
Moreover, the authors found that the package inserts (as compiled in the widely used Physicians’ Desk Reference) were correct about sleep-related effects for only 60 percent of the drugs. Don’t stop taking medication without first consulting your doctor.
Also see Solving Your Sleep Problems.