If you’re taking low-dose aspirin to help prevent heart disease, limit or avoid ibuprofen, since it can block the aspirin’s beneficial anti-clotting effect. The Food and Drug Administration (FDA) advises not taking ibuprofen during the eight hours before or half hour after taking plain, uncoated aspirin.
But because most low-dose aspirin is enteric-coated, it takes longer to be absorbed, so ibuprofen may interfere with it over a longer period. That means there’s no clear way to avoid the interaction. Ibuprofen is the active ingredient in pain relievers such as Advil and Motrin and is also found in some cold and sinus products.
Acetaminophen (such as Tylenol) and naproxen (such as Aleve) do not interact with aspirin.