November 22, 2017
NSAIDs and SSRIs

NSAIDs and SSRIs

by Berkeley Wellness  

Besides the many well-known interactions over-the-counter pain relievers can have with other drugs, researchers recently discovered a new one. Depressed people taking nonsteroidal anti-inflammatory drugs (NSAIDs) are about 25 percent less likely to have their symptoms relieved by the widely used antidepressants called selective serotonin reuptake inhibitors (SSRIs), such as Prozac and Paxil, according to a recent study published in the Proceedings of the National Academy of Sciences.

This is a double whammy, since earlier research found that combining SSRIs and NSAIDs greatly increases the risk of gastrointestinal bleeding. Acetaminophen is thus a better option for people taking SSRIs.